article
Metabolic and hematologic consequences of colectomy associated to hepatectomy in rats
Fecha
2011Registro en:
CARVALHO, Marília Daniela Ferreira; ARAUJO FILHO, Irami ; AZEVEDO, Ítalo Medeiros de ; REGO, Amália Cínthia Meneses; MEDEIROS, Aldo. Cunha . Metabolic and hematologic consequences of colectomy associated to hepatectomy in rats. Acta Cirurgica Brasileira, v. 26, p. 503-507, 2011.
1678-2674
Autor
Carvalho, Marília Daniela Ferreira
Araújo Filho, Irami
Azevedo, Ítalo Medeiros
Rêgo, Amália Cínthia Meneses
Medeiros, Aldo Cunha
Resumen
To investigate the influence of partial colectomy associated with hepatectomy on the biodistribution of the 99mTc-phytate,
on metabolic parameters, as well as labeling and morphology of red blood cells.
METHODS: Wistar rats were distributed into three groups (each with six), nominated as colectomy, colectomy+hepatectomy and
sham. In the 30th postoperative day all rats were injected with 99mTc-phytate 0.1mL i.v. (radioactivity 0.66 MBq). After 15 minutes, liver
sample was harvested and weighed. Percentage radioactivity per gram of tissue (%ATI/g) was determined using an automatic gammacounter.
Serum AST, ALT, alkaline phosphatase and red blood cells labeling were determined.
RESULTS: The liver %ATI/g and red blood cells labeling were lower in colectomy and colectomy+hepatectomy rats than in sham rats
(p <0.05), and no difference was detected comparing the colectomy and colectomy+hepatectomy groups. Red blood cells morphology did not differ among groups. Serum levels of AST, ALT and alkaline fosfatase were significantly higher in colectomy+hepatectomy than in colectomy rats (p<0.001).
CONCLUSION: Hepatectomy associated with colectomy lowered the uptake of radiopharmaceutical in liver and in red blood cells in rats, coinciding with changes in liver enzymatic activity.