Biodistribution of the Radiopharmaceutical Technetium- 99m-Sodium Phytate in Rats After Splenectomy

dc.creatorPereira, Kércia Regina Santos Gomes
dc.creatorAçucena, Maria Kadja Meneses Torres
dc.creatorVillarim Neto, Arthur
dc.creatorRêgo, Amália Cínthia Meneses
dc.creatorBernardo Filho, Mário
dc.creatorAzevedo, Ítalo Medeiros
dc.creatorAraújo Filho, Irami
dc.creatorMedeiros, Aldo Cunha
dc.date.accessioned2013-10-21T18:21:29Z
dc.date.accessioned2022-10-06T13:24:08Z
dc.date.available2013-10-21T18:21:29Z
dc.date.available2022-10-06T13:24:08Z
dc.date.created2013-10-21T18:21:29Z
dc.date.issued2008
dc.identifierPEREIRA, Kércia Regina Santos Gomes ; AÇUCENA, Maria Kadja Meneses Torres ; VILLARIM NETO, Arthur ; RÊGO, Amália Cínthia Meneses; BERNARDO FILHO, Mário; AZEVEDO, Ítalo Medeiros; ARAÚJO FILHO, Irami; MEDEIROS, Aldo Cunha. Biodistribution of the radiopharmaceutical technetium-99m-sodium phytate in rats after splenectomy. Brazilian Archives of Biology and Technology , v. 51, p. 203-207, 2008. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700033> Acesso em: 09 out. 2013.
dc.identifier1516-8913
dc.identifierhttps://repositorio.ufrn.br/jspui/handle/1/6625
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3968143
dc.description.abstractDrugs and surgery can interfere with the biodistribution of radiopharmaceuticals and data about the effect of splenectomy on the metabolism of phytate-Tc-99m are scarce. This study aimed at evaluating the interference of splenectomy on phytate-Tc-99m biodistribution and liver function in rats. The SP group rats (n=6) underwent splenectomy. In group C (control) the animals were not operated on. After 15 days, all rats were injected with 0.1mL of Tc-99m-phytate via orbital plexus (0.66MBq). After 30 minutes, liver samples were harvested, weighed and the percentage of radioactivity per gram (%ATI-g) was determined by a Wizard Perkin-Elme gama counter. The ATI%-g in splenectomized rats (0.99±0.02) was significantly higher than in controls (0.4±0.02), (p=0.034). ALT, AST and HDL were significantly lower in SP rats (p= 0.001) and leukocytosis was observed in SP rats. In conclusion, splenectomy in rats changed the hepatic biodistribution of Tc-99m-phytate and liver enzimatic activity
dc.languageeng
dc.rightsAcesso Aberto
dc.subjectSplenectomy
dc.subjectSodium phytate
dc.subjectBiodistribution
dc.subjectLiver
dc.titleBiodistribution of the Radiopharmaceutical Technetium- 99m-Sodium Phytate in Rats After Splenectomy
dc.typearticle


Este ítem pertenece a la siguiente institución