Effect of Tripanosomicide Benznidazole (Rochagan®) on the Biodistribution of Sodium Pertechnetate (Na99mTcO4) in Wistar Rats

dc.creatorBarbosa, Vanessa Santos de Arruda
dc.creatorHolanda, Cecília Maria de Carvalho Xavier
dc.creatorSilva, Roseane Pereira da
dc.creatorOliveira, Daniel Pereira de
dc.creatorSilva Júnior, Maurício Ferreira da
dc.creatorOliveira, Elias Herculano de
dc.creatorSpyrides, Maria Helena Constantino
dc.creatorMedeiros, Aldo Cunha
dc.date.accessioned2013-09-24T17:34:12Z
dc.date.accessioned2022-10-06T13:07:01Z
dc.date.available2013-09-24T17:34:12Z
dc.date.available2022-10-06T13:07:01Z
dc.date.created2013-09-24T17:34:12Z
dc.date.issued2008
dc.identifierBARBOSA, Vanessa Santos de Arruda ; HOLANDA, Cecília Maria de Carvalho Xavier ; SILVA, Roseane Pereira da ; OLIVEIRA, Daniel Pereira de ; SILVA JÚNIOR, Maurício Ferreira da ; OLIVEIRA, Elias Herculano de ; SPYRIDES, Maria Helena Constantino ; MEDEIROS, Aldo Cunha. Effect of tripanosomicide benznidazole (Rochagan ) on the biodistribution of sodium pertechnetate (Na99mTcO4) in Wistar rats. Brazilian Archives of Biology and Technology , v. 51, p. 175-180, 2008. Disponível em: <http://www.scielo.br/scielo.php?pid=s1516-89132008000700028&script=sci_arttext>. Acesso em: 19 set. 2013.
dc.identifier1516-8913
dc.identifierhttps://repositorio.ufrn.br/jspui/handle/1/6282
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3964112
dc.description.abstractBenznidazole, a drug with specific anti-Trypanosoma cruzi activity, is used in the treatment of Chagas’ disease. The radiopharmaceutical sodium pertechnetate (Na99mTcO4) is used to obtain diagnostic images of the stomach, thyroid, parathyroids, salivary glands, brain and in the study of esophageal reflux and blood flow. This study aimed at evaluating in vivo the influence of benznidazole treatment on the sodium pertechnetate biodistribution in Wistar rats. The percentage of radioactivity per gram (%ATI/g) of various organs (brain, heart, esophagus, stomach, small intestine, large intestine, spleen, liver, muscle and blood) was determined. Comparing the treated rats with the controls, we observed that sodium pertechnetate biodistribution did not change when administered to rats treated for thirty days with benznidazole
dc.languageeng
dc.rightsAcesso Aberto
dc.subjectAntiparasite
dc.subjectRadiopharmaceutical
dc.subjectTechnetium-99m
dc.subjectBenznidazole
dc.subjectBiodistribution
dc.subjectTrypanosoma cruzi
dc.titleEffect of Tripanosomicide Benznidazole (Rochagan®) on the Biodistribution of Sodium Pertechnetate (Na99mTcO4) in Wistar Rats
dc.typearticle


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