masterThesis
Estado nutricional e hormônios relacionados com o apetite em crianças e adolescentes com leucemia durante a fase de indução da quimioterapia
Fecha
2016-11-10Registro en:
GOMES, Camila de Carvalho. Estado nutricional e hormônios relacionados com o apetite em crianças e adolescentes com leucemia durante a fase de indução da quimioterapia. 2016. 66f. Dissertação (Mestrado em Nutrição) - Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal, 2016.
Autor
Gomes, Camila de Carvalho
Resumen
Cancer is a group of several diseases that have in common an uncontrolled
proliferation of abnormal cells, and it can occur at anywhere in the body. The most
frequent tumors in childhood and adolescence are the leukemias, and the Acute
Lymphoblastic Leukemia (ALL) is the most prevalent. The evidenced malnutrition in
these patients is related to anorexia-cachexia syndrome triggered by the disease, but
also on changes in appetite, which occur during chemotherapy and interfere in the
nutritional status as well as in response to antineoplasic therapy. Although it
recognized a possible influence of hormones related to appetite on the changes in food
consumption of ALL patients during chemotherapy, few studies have investigated the
hormonal changes in patients with childhood cancers. Thus, the aim of this study was
to evaluate the nutritional status and levels of key hormones related to appetite in
children and adolescents with Acute Lymphoblastic Leukemia (ALL) in the induction
phase of chemotherapy. For this purpose, it was assessed 14 children/adolescents
diagnosed with ALL during the 28 days of induction chemotherapy cycle. At baseline
(prior to initiation of chemotherapy), in the middle and at the end of this cycle were
performed anthropometric measurement, weighted food record 24 hours and
biochemical and hormone levels were obtained. It were evaluated the following
hormones related to appetite: leptin, ghrelin, insulin and cortisol. Most patients had
normal weight at the beginning of treatment which did not change significantly during
the induction cycle. The dietary intake increased over the cycle, particularly in relation
to proteins and lipids intake from the beginning to the end of treatment. Platelet levels
and transaminase glutamic pyruvic significantly increased, and a significant reduction
in blood glucose, creatinine and sodium levels were observed. Regarding appetite
hormones, ghrelin significantly increased between the baseline and the half of the
cycle (p = 0.027), but not through the end. In conclusion, the ALL treatment induction
period caused an increase in energy and nutrients intake, as well as an increase in the
concentration of ghrelin, but no impact on the anthropometric status of patients or in
other hormones related to appetite.