doctoralThesis
Análise da expressão imuno-histoquímica da ciclofilina A, EMMPRIN e MMP-7 na doença periodontal
Fecha
2013-09-13Registro en:
NÓBREGA, Fernando José de Oliveira. Análise da expressão imuno-histoquímica da ciclofilina A, EMMPRIN e MMP-7 na doença periodontal. 2013. 107 f. Tese (Doutorado em Odontologia) - Universidade Federal do Rio Grande do Norte, Natal, 2013.
Autor
Nóbrega, Fernando José de Oliveira
Resumen
Periodontal disease is an infectious disease resulting from the immunoinflammatory
response of the host to microorganisms present in the dental biofilm which causes
tissue destruction. The objective of this study was to evaluate the
immunohistochemical expression of cyclophilin A (CYPA), extracellular matrix
metalloproteinase inducer (EMMPRIN) and matrix metalloproteinase 7 (MMP-7) in
human specimens of clinically healthy gingiva (n=32), biofilm-induced gingivitis
(n=28), and chronic periodontitis (n=30). Immunopositivity for CYPA, EMMPRIN and
MMP-7 differed significantly between the three groups, with higher percentages of
staining in chronic periodontitis specimens, followed by chronic gingivitis and healthy
gingiva specimens (p < 0.001). Immunoexpression of CYPA and MMP-7 was higher
in the intense inflammatory infiltrate observed mainly in cases of periodontitis.
Analysis of possible correlations between the immunoexpression of EMMPRIN,
MMP-7 and CYPA and between the expression of these proteins and clinical
parameters (probing depth and clinical attachment loss) showed a positive
correlation of CYPA expression with MMP-7 (r = 0.831; p < 0.001) and EMMPRIN (r
= 0.289; p = 0.006). In addition, there was a significant positive correlation between
probing depth and expression of MMP-7 (r = 0.726; p < 0.001), EMMPRIN (r = 0.345;
p = 0.001), and CYPA (r = 0.803; p < 0.001). These results suggest that CYPA,
EMMPRIN and MMP-7 are associated with the pathogenesis and progression of
periodontal disease