doctoralThesis
Estudo da expressão imuno-histoquímica das MMPs -2, -7, -9 e -26 e TIMPs -1 e -2 em adenomas pleomórficos e carcinomas adenóides císticos de glândulas salivares menores
Fecha
2011-02-24Registro en:
FREITAS, Valéria Souza. Estudo da expressão imuno-histoquímica das MMPs -2, -7, -9 e -26 e TIMPs -1
e -2 em adenomas pleomórficos e carcinomas adenóides císticos de glândulas
salivares menores. 2011. 156 f. Tese (Doutorado em Odontologia) - Universidade Federal do Rio Grande do Norte, Natal, 2011.
Autor
Freitas, Valéria Souza
Resumen
The balance between the expression of matrix metalloproteinases (MMPs) and their
tissue inhibitors (TIMPs) has been related to various physiological and pathological
processes, including salivary gland morphogenesis and tumor invasion and metastasis
processes. Pleomorphic adenoma (PA) and adenoid cystic carcinoma (ACC) respectively
represent benign and malignant neoplasias of salivary glands. Although they share the same
cell origin, they present distinct biological behavior. The aim of this study was to compare the
immunohistochemical expression of MMPs -2, -7, -9 and -26, and of TIMPs -1 and -2, in
cases of PA and ACC of minor salivary glands. Twenty cases of PA and twenty cases of ACC
were assessed according to the presence, intensity and location of MMPs and TIMPs in the
tumor parenchyma. Most of the PAs and ACCs presented a high expression of MMP -2, -7, -9
and -26 and of TIMP -1 and -2, predominantly located in tumor cells. There was no
significant difference in the expression of MMPs -2 (p=0.359), -7 (p=0.081) and -26
(p=0.553), as well as of TIMPs -1 (p=0.657) and -2 (p=0.248), between the parenchyma of
PAs and ACCs. However, MMP-9 showed a significant difference of expression between the
two tumors, with the ACC showing more intense marking for this gelatinase (p=0.041). The
strong expression of MMP-9 observed in the parenchyma suggests that this gelatinase may
play an important role in the biological behavior of these tumors. On the other hand, although
there was no significant difference between the marking of MMP -2, 7 and 26 in the studied
tumors, the data, when analyzed as a whole, suggest that these proteases may take part in the
process of tissue remodeling in both tumors, but do not present a direct relation with the
pattern of aggressiveness of ACC. Nonetheless, matrilisins may indirectly influence the
behavior of this tumor due to their capacity of activating MMP-9, strongly expressed in the
parenchyma of ACC