Artículos de revistas
Embriopatía por isotretinoína: Un daño evitable
Autor
Troncoso Sen,Mónica
Rojas H,Carla
Bravo C,Eduardo
Institución
Resumen
Retinoic acid is a widely used drug in the treatment of cystic acné. It has teratogenic effects that depend on the gestational period in which it is used. We report a seven months of female whose mother was exposed to retinoic acid in both pregestational and gestational periods. She had a retardation of psychomotor development and a brain MRI showed frontal atrophy and a malformation of the posterior fossa. We discuss the mechanisms ofthe teratogenic effeets of retinoic acid