Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion

dc.creatorGALARCE,GLORIA D
dc.creatorFONCEA,ROCÍO E
dc.creatorEDWARDS,ANA M
dc.creatorPESSOA-MAHANA,HERNÁN
dc.creatorPESSOA-MAHANA,CARLOS D
dc.creatorEBENSPERGER,ROBERTO A
dc.date2008-01-01
dc.date.accessioned2017-03-07T16:02:11Z
dc.date.available2017-03-07T16:02:11Z
dc.identifierhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000100006
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/394997
dc.descriptionThis study describes the effect of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as tumor necrosis factor alpha (TNF-á) production inhibitors. The newly synthesized compounds were tested for their in vitro ability to inhibit the lipolysaccharide (LPS) induced TNF-á secretion in the human promyelocytic cell line HL-60. The compound 6-Phenyl-benzimidazo [1,2-c] quinazoline, coded as Gl, resulted as the most potent inhibitor and with no significant cytotoxic activity. Thus, 6-Arylbenzimidazo [1,2-c] quinazoline derivatives may have a potential as anti-inflammatory agents
dc.formattext/html
dc.languageen
dc.publisherSociedad de Biología de Chile
dc.sourceBiological Research v.41 n.1 2008
dc.subjectanti-inflammatory agents
dc.subjectbenzimidazoquinazoline derivatives
dc.subjectTNF-á inhibitors
dc.titleBiological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion
dc.typeArtículos de revistas


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