Antioxidant effect of 5-amino salicylic acid on copper-mediated LDL oxidation

dc.creatorLÓPEZ-ALARCÓN,CAMILO
dc.creatorSPEISKY,HERNÁN
dc.creatorLISSI,EDUARDO
dc.date2007-01-01
dc.date.accessioned2017-03-07T16:01:18Z
dc.date.available2017-03-07T16:01:18Z
dc.identifierhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000200006
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/394711
dc.descriptionThe antioxidant effect of 5-Aminosalicylic acid (5-ASA) on copper-mediated LDL oxidation was followed either by the emitted chemiluminiscence (CL) or by UV-vis spectroscopy. 5-ASA addition extends the lag phase in a concentration-dependent manner without changes in the rate of the process in the autoaccelerated phase. The antioxidant behavior of 5-ASA was very similar to that of Trolox, a very efficient water soluble antioxidant. The copper-binding capacity of 5-ASA was evaluated by UV-visible spectroscopy. The addition of copper to a 5-ASA solution increases the absorbance at 332 nm and generates a new band at 298 nm. These changes in the UV-vis spectra indicate formation of a complex between 5-ASA and copper. However, LDL protection by 5-ASA is unrelated to its copper chelating capacity
dc.formattext/html
dc.languageen
dc.publisherSociedad de Biología de Chile
dc.sourceBiological Research v.40 n.2 2007
dc.subject5-Aminosalicylic acid
dc.subjectAntioxidant
dc.subjectLDL oxidation
dc.titleAntioxidant effect of 5-amino salicylic acid on copper-mediated LDL oxidation
dc.typeArtículos de revistas


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