dc.contributorEgito, Eryvaldo Sócrates Tabosa do
dc.contributor
dc.contributorhttp://lattes.cnpq.br/9506411475317395
dc.contributor
dc.contributorhttp://lattes.cnpq.br/6907806915889763
dc.contributorMaranhão, Técia Maria de Oliveira
dc.contributor
dc.contributorhttp://lattes.cnpq.br/7869140767244263
dc.contributorFonseca, José Luis Cardozo
dc.contributor
dc.contributorhttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4788562T6
dc.contributorBentley, Maria Vitória Lopes Badra
dc.contributor
dc.contributorhttp://lattes.cnpq.br/0771724992908427
dc.creatorOliveira, Elquio Eleamen
dc.date.accessioned2010-10-27
dc.date.accessioned2014-12-17T14:13:33Z
dc.date.accessioned2022-10-05T23:02:16Z
dc.date.available2010-10-27
dc.date.available2014-12-17T14:13:33Z
dc.date.available2022-10-05T23:02:16Z
dc.date.created2010-10-27
dc.date.created2014-12-17T14:13:33Z
dc.date.issued2010-06-07
dc.identifierOLIVEIRA, Elquio Eleamen. Novos sistemas de liberação de fármacos à base de xilana. 2010. 62 f. Tese (Doutorado em Ciências da Saúde) - Universidade Federal do Rio Grande do Norte, Natal, 2010.
dc.identifierhttps://repositorio.ufrn.br/jspui/handle/123456789/13181
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3945095
dc.description.abstractThe aim of this work was to perform the extraction and characterization of xylan from corn cobs and prepare xylan-based microcapsules. For that purpose, an alkaline extraction of xylan was carried out followed by the polymer characterization regarding its technological properties, such as angle of repose, Hausner factor, density, compressibility and compactability. Also, a low-cost and rapid analytical procedure to identify xylan by means of infrared spectroscopy was studied. Xylan was characterized as a yellowish fine powder with low density and poor flow properties. After the extraction and characterization of the polymer, xylan-based microcapsules were prepared by means of interfacial crosslinking polymerization and their characterization was performed in order to obtain gastroresistant multiparticulate systems. This work involved the most suitable parameters of the preparation of microcapsules as well as the study of the process, scale-up methodology and biological analysis. Magnetic nanoparticles were used as a model system to be encapsulated by the xylan microcapsules. According to the results, xylan-based microcapsules were shown to be resistant to several conditions found along the gastrointestinal tract and they were able to avoid the early degradation of the magnetic nanoparticles
dc.publisherUniversidade Federal do Rio Grande do Norte
dc.publisherBR
dc.publisherUFRN
dc.publisherPrograma de Pós-Graduação em Ciências da Saúde
dc.publisherCiências da Saúde
dc.rightsAcesso Aberto
dc.subjectXilana
dc.subjectEspectrofotometria de absorção na região do infravermelho
dc.subjectMicrocápsulas
dc.subjectLiberação cólon-específica
dc.subjectReticulação polimérica interfacial
dc.subjectXylan
dc.subjectinfrared spectroscopy
dc.subjectmicrocapsules
dc.subjectcolon-specific delivery
dc.subjectinterfacial cross-linking polymerization
dc.titleNovos sistemas de liberação de fármacos à base de xilana
dc.typedoctoralThesis


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