article
Biodistribution of technetium-99m pertechnetate after Roux-en-Y gastric bypass (Capella technique) in rats
Fecha
2010Registro en:
1678-2674
Autor
Rêgo, Amália Cínthia Meneses do
Araújo Filho, Irami
Azevedo, Ítalo Medeiros
Jácome, Daniel Tôrres
Ramalho, Rachel de Alcântara Oliveira
Medeiros, Aldo Cunha
Resumen
The biodistribution of sodium pertechnetate, the most used radiopharmaceutical in nuclear medicine, has not been studied in
details after bariatric surgery. The objective was to investigate the effect of Roux-en-Y gastric bypass (RYGB) on biodistribution of
sodium pertechnetate (Na99mTc-) in organs and tissues of rats. Methods: Twelve rats were randomly divided into two groups of 6 animals
each. The RYGB group rats were submitted to the Roux-en-Y gastric bypass and the control group rats were not operated. After 15 days,
all rats were injected with 0.1mL of Na99mTc- via orbital plexus with average radioactivity of 0.66 MBq. After 30 minutes, liver, stomach,
thyroid, heart, lung, kidney and femur samples were harvested, weighed and percentage of radioactivity per gram (%ATI/g) of each
organ was determined by gama counter Wizard Perkin-Elmer. We applied the Student t test for statistical analysis, considering p<0.05 as
significant. Results: Significant reduction in mean %ATI/g was observed in the liver, stomach and femur in the RYGB group animals,
compared with the control group rats (p<0.05). In other organs no significant difference in %ATI/g was observed between the two
groups. Conclusion: This work contributes to the knowledge that the bariatric surgery RYGB modifies the pattern of biodistribution of
Na99mTc