article
Synthesis and characterization of xylan-coated magnetite microparticles
Registro en:
0378-5173
10.1016/j.ijpharm.2006.10.019
Autor
Araújo, Jose Humberto de
Silva, Amanda Karina Andriola
Silva, Érica L. da
Oliveira, Elquio Eleamen
Soares, Luiz Alberto Lira
Nagashima Junior, Toshiyuiky
Medeiros, Aldo C.
Araújo, Ivonete Batista de
Carriço, Artur Silva
Egito, Eryvaldo Sócrates Tabosa do
Resumen
This work evaluates an experimental set-up to coat superparamagnetic particles in order to protect them from gastric dissolution. First, magnetic particles were produced by coprecipitation of iron salts in alkaline medium. Afterwards, an emulsification/cross-linking reaction was carried out in order to produce magnetic polymeric particles. The sample characterization was performed by X-ray powder diffraction, laser scattering particle size analysis, optical microscopy, thermogravimetric analysis and vibrating sample magnetometry. In vitro dissolution tests at gastric pH were evaluated for both magnetic particles and magnetic polymeric particles. The characterization data have demonstrated the feasibility of the presented method to coat, and protect magnetite particles from gastric dissolution. Such systems may be very promising for oral administration