Brasil | Artigo
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-27T11:30:43Z
dc.date.accessioned2022-10-05T18:59:51Z
dc.date.available2014-05-27T11:30:43Z
dc.date.available2022-10-05T18:59:51Z
dc.date.created2014-05-27T11:30:43Z
dc.date.issued2013-09-23
dc.identifierNatural Product Research, v. 27, n. 18, p. 1646-1650, 2013.
dc.identifier1478-6419
dc.identifier1478-6427
dc.identifierhttp://hdl.handle.net/11449/76618
dc.identifier10.1080/14786419.2012.742078
dc.identifierWOS:000324087900006
dc.identifier2-s2.0-84884250067
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3925499
dc.description.abstractA possible immunomodulatory/anti-inflammatory effect of Baccharis dracunculifolia (Bd) and its major compound - caffeic acid (Ca) - on cytokines production (IL-1b, IL-6 and IL-10) by murine macrophages was investigated. Cells were incubated with Bd and Ca, and the inhibitory concentrations were tested before or after macrophages challenge with LPS. Bd and Ca stimulated IL-1b and inhibited IL-6 and IL-10 production. In LPS-challenge protocols, Bd prevented LPS action either before or after LPS challenge, whereas Ca prevented LPS effects only after LPS addition. Bd modulatory action on cytokines production may be at least in part mediated by Ca, since it has been shown to inhibit the transcription factor NF-kB. Further studies are still needed to evaluate Bd efficacy in inflammatory diseases, in order to explore its antiinflammatory activity in vivo. © 2013 Taylor & Francis.
dc.languageeng
dc.relationNatural Product Research
dc.relation1.928
dc.relation0,671
dc.rightsAcesso restrito
dc.sourceScopus
dc.subjectBaccharis dracunculifolia
dc.subjectCaffeic acid
dc.subjectCytokines
dc.subjectImmunomodulation
dc.subject2,2 dimethyl 6 carboxyethenyl 2h 1 benzopyran acid
dc.subjectantiinflammatory agent
dc.subjectartepilin C
dc.subjectBaccharis dracunculifolia extract
dc.subjectcaffeic acid
dc.subjectdexamethasone
dc.subjectferulic acid
dc.subjectimmunoglobulin enhancer binding protein
dc.subjectimmunomodulating agent
dc.subjectinterleukin 10
dc.subjectinterleukin 1beta
dc.subjectinterleukin 6
dc.subjectisosakuranetin
dc.subjectlipopolysaccharide
dc.subjectplant extract
dc.subjectunclassified drug
dc.subjectveratraldehyde
dc.subjectanimal cell
dc.subjectantiinflammatory activity
dc.subjectcontrolled study
dc.subjectcytokine production
dc.subjectdrug mechanism
dc.subjectimmunomodulation
dc.subjectin vitro study
dc.subjectmouse
dc.subjectnonhuman
dc.subjectperitoneum macrophage
dc.subjectplant leaf
dc.subjectprovocation test
dc.titleImmunomodulatory/anti-inflammatory effects of Baccharis dracunculifolia leaves
dc.typeArtigo


Este ítem pertenece a la siguiente institución