Trabalho apresentado em evento
Electrochemical determination of antimalarial drug amodiaquine in maternal milk using a hemin-based electrode
Fecha
2012-12-01Registro en:
ECS Transactions, v. 43, n. 1, p. 297-304, 2012.
1938-5862
1938-6737
10.1149/1.4704970
2-s2.0-84879424595
0072173018005712
0000-0002-2296-1393
Autor
Universidade Federal de Sergipe (UFS)
Universidade Estadual Paulista (Unesp)
Resumen
Voltammetric analysis of amodiaquine using a hemin biosensor revealed a well-defined peak at 0.14 V (vs. Ag/AgCl), corresponding to the oxidation of amodiaquine at pH 7.0. The electrodic behavior indicated that the oxidation process was irreversible, and that it was controlled by diffusion. In addition to advantages such as high selectivity and sensitivity, the method developed could be used for the analysis of breast milk containing amodiaquine without any need for prior sample treatment, an important consideration in routine analysis laboratories. Measurements of the drug contained in breast milk were used to validate the technique. The detection limit for standard solutions was 3.30 mg L-1, and the quantification limit was 11.0 mg L-1. ©The Electrochemical Society.