Variation in the CXCR1 gene (IL8RA) is not associated with susceptibility to chronic periodontitis

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:26:06Z
dc.date.accessioned2022-10-05T18:29:41Z
dc.date.available2014-05-27T11:26:06Z
dc.date.available2022-10-05T18:29:41Z
dc.date.created2014-05-27T11:26:06Z
dc.date.issued2011-11-04
dc.identifierJournal of Negative Results in BioMedicine, v. 10, n. 1, 2011.
dc.identifier1477-5751
dc.identifierhttp://hdl.handle.net/11449/72787
dc.identifier10.1186/1477-5751-10-14
dc.identifier2-s2.0-80155201284
dc.identifier2-s2.0-80155201284.pdf
dc.identifier2628593693450121
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3921818
dc.description.abstractBackground: The chemokine receptor 1 CXCR-1 (or IL8R-alpha) is a specific receptor for the interleukin 8 (IL-8), which is chemoattractant for neutrophils and has an important role in the inflammatory response. The polymorphism rs2234671 at position Ex2+860G > C of the CXCR1 gene causes a conservative amino acid substitution (S276T). This single nucleotide polymorphism (SNP) seemed to be functional as it was associated with decreased lung cancer risk. Previous studies of our group found association of haplotypes in the IL8 and in the CXCR2 genes with the multifactorial disease chronic periodontitis. In this study we investigated the polymorphism rs2234671 in 395 Brazilian subjects with and without chronic periodontitis. Findings. Similar distribution of the allelic and genotypic frequencies were observed between the groups (p > 0.05). Conclusions: The polymorphism rs2234671 in the CXCR1 gene was not associated with the susceptibility to chronic periodontitis in the studied Brazilian population. © 2011 Scarel-Caminaga et al; licensee BioMed Central Ltd.
dc.languageeng
dc.relationJournal of Negative Results in BioMedicine
dc.relation0,483
dc.rightsAcesso aberto
dc.sourceScopus
dc.subjectchemokine
dc.subjectCXCR1
dc.subjectcytokine
dc.subjectgenetic polymorphism
dc.subjectperiodontal disease
dc.subjectchemokine receptor CXCR1
dc.subjectadult
dc.subjectchronic periodontitis
dc.subjectdisease predisposition
dc.subjectfemale
dc.subjectgene frequency
dc.subjectgenetic variability
dc.subjectgenotype
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectsingle nucleotide polymorphism
dc.subjectgenetic predisposition
dc.subjectgenetics
dc.subjecthaplotype
dc.subjectmiddle aged
dc.subjectAdult
dc.subjectChronic Periodontitis
dc.subjectFemale
dc.subjectGenetic Predisposition to Disease
dc.subjectGenetic Variation
dc.subjectHaplotypes
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPolymorphism, Single Nucleotide
dc.subjectReceptors, Interleukin-8A
dc.titleVariation in the CXCR1 gene (IL8RA) is not associated with susceptibility to chronic periodontitis
dc.typeArtigo


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