Síntese e atividade biológica do derivado 6-formil-oxamniquina

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Estadual de Campinas (UNICAMP)
dc.contributorUniversidade Federal de São Carlos (UFSCar)
dc.date.accessioned2014-05-27T11:23:41Z
dc.date.accessioned2022-10-05T18:13:33Z
dc.date.available2014-05-27T11:23:41Z
dc.date.available2022-10-05T18:13:33Z
dc.date.created2014-05-27T11:23:41Z
dc.date.issued2008-10-01
dc.identifierRevista Brasileira de Ciencias Farmaceuticas/Brazilian Journal of Pharmaceutical Sciences, v. 44, n. 4, p. 749-754, 2008.
dc.identifier1516-9332
dc.identifierhttp://hdl.handle.net/11449/70603
dc.identifier10.1590/S1516-93322008000400022
dc.identifierS1516-93322008000400022
dc.identifierWOS:000263804500022
dc.identifier2-s2.0-59649108290
dc.identifier2-s2.0-59649108290.pdf
dc.identifier8221737491598415
dc.identifier9734333607975413
dc.identifier0000-0003-4141-0455
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3919877
dc.description.abstractSchistosomiasis, an important disease in Brazil, is caused by a trematode of the genus Schistosoma, reaching millions of person in one of the most endemic region of this disease in the whole globe. The main goal of this work was to syntetize the 6-formyl- oxamniquine derivative and evaluate its biological activity. The 6-formyl-oxamniquine derivative was obtained by the oxidation of oxamniquine with MnO 2, applying CH 2Cl 2 as solvent at room temperature for 24 hours. The obtaintion of 6-formyl-oxamniquine derivative compound was confirmed by IR spectroscopy and 13C NMR and 1H NMR, presenting similar activity when compared to the commercial oxamniquine (Mansil®).
dc.languagepor
dc.relationRevista Brasileira de Ciencias Farmaceuticas/Brazilian Journal of Pharmaceutical Sciences
dc.rightsAcesso aberto
dc.sourceScopus
dc.subjectOoxamniquine
dc.subjectSchistosoma mansoni
dc.subjectSchistosomiasis
dc.subject6 formyl oxamniquine derivative
dc.subjectmanganese oxide
dc.subjectoxamniquine
dc.subjectunclassified drug
dc.subjectBrazil
dc.subjectcarbon nuclear magnetic resonance
dc.subjectdrug activity
dc.subjectdrug structure
dc.subjectdrug synthesis
dc.subjectinfrared spectroscopy
dc.subjectproton nuclear magnetic resonance
dc.subjectschistosomiasis
dc.titleSíntese e atividade biológica do derivado 6-formil-oxamniquina
dc.typeArtigo


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