Síntese e atividade biológica do derivado 6-formil-oxamniquina

Artigo

Fecha

2008-10-01

Registro en:

Revista Brasileira de Ciencias Farmaceuticas/Brazilian Journal of Pharmaceutical Sciences, v. 44, n. 4, p. 749-754, 2008.

1516-9332

http://hdl.handle.net/11449/70603

10.1590/S1516-93322008000400022

S1516-93322008000400022

WOS:000263804500022

2-s2.0-59649108290

2-s2.0-59649108290.pdf

8221737491598415

9734333607975413

0000-0003-4141-0455

http://repositorioslatinoamericanos.uchile.cl/handle/2250/3919877

Autor

Universidade Estadual Paulista (Unesp)

Universidade Estadual de Campinas (UNICAMP)

Universidade Federal de São Carlos (UFSCar)

Institución

Universidade Paulista Júlio de Mesquita Filho (Brasil)

Resumen

Schistosomiasis, an important disease in Brazil, is caused by a trematode of the genus Schistosoma, reaching millions of person in one of the most endemic region of this disease in the whole globe. The main goal of this work was to syntetize the 6-formyl- oxamniquine derivative and evaluate its biological activity. The 6-formyl-oxamniquine derivative was obtained by the oxidation of oxamniquine with MnO 2, applying CH 2Cl 2 as solvent at room temperature for 24 hours. The obtaintion of 6-formyl-oxamniquine derivative compound was confirmed by IR spectroscopy and 13C NMR and 1H NMR, presenting similar activity when compared to the commercial oxamniquine (Mansil®).