Comparative study of disk diffusion and microdilution methods for evaluation of antifungal activity of natural compounds against medical yeasts Candida spp and Cryptococcus sp

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:22:43Z
dc.date.accessioned2022-10-05T18:10:20Z
dc.date.available2014-05-27T11:22:43Z
dc.date.available2022-10-05T18:10:20Z
dc.date.created2014-05-27T11:22:43Z
dc.date.issued2007-12-01
dc.identifierRevista de Ciencias Farmaceuticas Basica e Aplicada, v. 28, n. 1, p. 25-34, 2007.
dc.identifier1808-4532
dc.identifier2179-443X
dc.identifierhttp://hdl.handle.net/11449/70145
dc.identifier2-s2.0-39549090162
dc.identifier2-s2.0-39549090162.pdf
dc.identifier4702004904231248
dc.identifier4484083685251673
dc.identifier0000-0002-8059-0826
dc.identifier0000-0002-1516-7765
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3919488
dc.description.abstractAntifungal activity of natural products has been tested by adapting methods designed for synthetic drugs. In this study, two methods for the determination of antifungal activity of natural products, agar diffusion and broth microdilution, the CLSI reference methods for synthetic drugs, are compared and discussed. The microdilution method was more sensitive. The minimal inhibitory concentrations (MIC) of crude extracts, fractions and pure substances from different species of the plant families Piperaceae, Rubiaceae, Clusiaceae, Fabaceae and Lauraceae, from the Biota project, were determined. Antifungal activities against Candida albicans, C.krusei, C.parapsilosis and Cryptococcus neoformans were produced by several samples.
dc.languageeng
dc.relationRevista de Ciências Farmacêuticas Básica e Aplicada
dc.relation0,131
dc.rightsAcesso aberto
dc.sourceScopus
dc.subjectAntifungal activity
dc.subjectCandida sp
dc.subjectCryptococcus sp
dc.subjectNatural products
dc.subjectantifungal agent
dc.subjectclusiaceae extract
dc.subjectfabaceae extract
dc.subjectlauraceae extract
dc.subjectpiperaceae extract
dc.subjectplant extract
dc.subjectrubiaceae extract
dc.subjectunclassified drug
dc.subjectangiosperm
dc.subjectantibiotic sensitivity
dc.subjectantifungal activity
dc.subjectbroth dilution
dc.subjectCandida albicans
dc.subjectCandida krusei
dc.subjectCandida parapsilosis
dc.subjectcomparative study
dc.subjectCryptococcus neoformans
dc.subjectdisk diffusion
dc.subjectdrug activity
dc.subjectdrug determination
dc.subjectdrug screening
dc.subjectGuttiferae
dc.subjectlegume
dc.subjectminimum inhibitory concentration
dc.subjectnonhuman
dc.subjectPiperaceae
dc.subjectRubiaceae
dc.subjectsensitivity and sensibility
dc.subjectyeast
dc.titleComparative study of disk diffusion and microdilution methods for evaluation of antifungal activity of natural compounds against medical yeasts Candida spp and Cryptococcus sp
dc.typeArtigo


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