Artigo
Cytomegalovirus and Toxoplasma gondii seroprevalence in a Brazilian liver transplant waiting list
Fecha
2007-12-01Registro en:
Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 13, n. 4, p. 881-884, 2007.
1678-9199
10.1590/S1678-91992007000400016
S1678-91992007000400016
WOS:000251325200016
2-s2.0-38349095287
2-s2.0-38349095287.pdf
6322604200510676
7280217167642056
0208138450121898
0000-0003-0567-6221
Autor
Universidade Estadual Paulista (Unesp)
Resumen
Cytomegalovirus (CMV) disease is a major cause of morbidity and mortality in solid organ transplantation. Disseminated toxoplasmosis after liver transplantation is a rare but fatal event. Serologic screening of the donor and the recipient is essential to prophylactic management, early diagnosis and therapeutic strategies to minimize the consequences of these infections. The aim of the present study was to determine the seroprevalence of CMV and Toxoplasma gondii (TG) in a Brazilian liver transplant waiting list (LTWL). Serological data were collected from 44 candidates on the LTWL between May 2003 and November 2004. Serological investigation of antibodies IgM and IgG against CMV (anti-CMV) and TG (anti-T. gondii) was performed using fluorometry commercial kits. IgG anti-CMV was positive in 37 patients (94.9%) out of 39 available results. There were not IgM anti-CMV positive results. Out of 36 analyzed patients, 22 (61.1%) presented positive IgG anti-T. gondii and none had positive IgM anti-T. gondii. The high CMV seroprevalence among our LTWL reinforces the need for appropriate protocols to avoid related complications, like reactivation and superinfection by CMV. Environmental and drug prophylactic strategies against primary infection and reactivation, as well as early diagnosis and treatment of toxoplasmosis complications, are essential for the good outcome of transplant patients.