Artigo
Transmission analysis of candidate genes for nonsyndromic oral clefts in Brazilian parent-child triads with recurrence
Fecha
2006-09-20Registro en:
Genetics and Molecular Biology, v. 29, n. 3, p. 439-442, 2006.
1415-4757
1678-4685
10.1590/S1415-47572006000300005
S1415-47572006000300005
WOS:000240328500005
2-s2.0-33748650083
2-s2.0-33748650083.pdf
0000-0002-9256-7623
Autor
Universidade Estadual Paulista (Unesp)
Universidade de São Paulo (USP)
University of Pittsburgh
Resumen
Cleft lip and/or palate (CL/P) is a major congenital defect with complex etiology, including multiple genetic and environmental factors. Approximately two thirds of the cases are not accompanied by other anomalies and are called nonsyndromic (NS). In the present study, we performed transmission distortion analysis of the MSX1-CA, TGFB3-CA and MTHFR-C677T polymorphisms in 60 parent-child triads, in which the NS-CL/ P affected child had at least one affected parent. No association with genes MSX1 or TGFB3 was found, but the results were suggestive of an association of the MTHFR-C677T polymorphism with NS-CL/P. © 2006 Sociedade Brasileira de Genética.
Materias
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Oral health-related quality of life in children in Chile treated for cleft lip and palate: A case-control approach
Aravena P.C.; Gonzalez T.; Oyarzún T.; Coronado C. (American Cleft Palate Craniofacial Association, 2017) -
High dosage folic acid supplementation, oral cleft recurrence and fetal growth
Wehby, George L.; Félix, Têmis Maria; Goco, Norman; Richieri-Costa, Antonio; Chakraborty, Hrishikesh; Souza, Josiane; Pereira, Rui; Padovani, Carla; Moretti-Ferreira, Danilo; Murray, Jeffrey C. -
High dosage folic acid supplementation, oral cleft recurrence and fetal growth
University of Iowa; Hospital de Clínicas de Porto Alegre; RTI International, Research Triangle Park; Hospital de Reabilitação de Anomalias Craniofaciais; University of South Carolina; Centro de Atendimento Integral ao Fissurado Lábio Palatal; Instituto Materno Infantil Prof. Fernando Figueira-CADEFI/IMIP; Hospital Santo Antônio: Obras Sociais Irmã Dulce, Salvador; Universidade Estadual Paulista (Unesp) (2013-02-01)Objectives: To evaluate the effects of folic acid supplementation on isolated oral cleft recurrence and fetal growth. Patients and Methods: The study included 2,508 women who were at-risk for oral cleft recurrence and ...