Human chromosome aberrations induced in vitro by Paracoccidioides brasiliensis glycoproteic component (GP 43)

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorTriangulo Mineiro Medical School
dc.date.accessioned2014-05-27T11:18:13Z
dc.date.accessioned2022-10-05T17:33:49Z
dc.date.available2014-05-27T11:18:13Z
dc.date.available2022-10-05T17:33:49Z
dc.date.created2014-05-27T11:18:13Z
dc.date.issued1997-04-24
dc.identifierMutation Research - Genetic Toxicology and Environmental Mutagenesis, v. 390, n. 1-2, p. 5-10, 1997.
dc.identifier1383-5718
dc.identifierhttp://hdl.handle.net/11449/65090
dc.identifier10.1016/S0165-1218(96)00148-6
dc.identifierWOS:A1997WV93700002
dc.identifier2-s2.0-0030973326
dc.identifier0000-0002-8059-0826
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3915052
dc.description.abstractThe in vitro cytogenetic effects of the 43-kDa molecular mass exocellular glycoproteic component (GP 43) from Paracoccidioides brasiliensis were studied in cultures from human lymphocytes. The sample included 10 healthy, white, non-smoking, non-related males (mean age of 31.3 ± 8.2 years). Besides the control, three concentrations of GP 43 (0.125, 1.25 and 5 μg/ml) were used. In each group, around 1000 cells were examined in search of chromosome aberrations, and 30,000 metaphases were analysed for the determination of the Mitotic Index. The authors conclude that GP 43 most probably causes inhibition of the cell cycle and aneugenic and clastogenic effects.
dc.languageeng
dc.relationMutation Research: Genetic Toxicology and Environmental Mutagenesis
dc.relation1.996
dc.relation0,747
dc.rightsAcesso restrito
dc.sourceScopus
dc.subjectChromosome aberration
dc.subjectCytogenetics
dc.subjectGP 43
dc.subjectMitotic index
dc.subjectMutagenesis
dc.subjectParacoccidioides brasiliensis
dc.subjectParacoccidioidomycosis
dc.subjectglycoprotein
dc.subjectadult
dc.subjectchromosome aberration
dc.subjectcontrolled study
dc.subjectcytogenetics
dc.subjecthuman
dc.subjecthuman cell
dc.subjectin vitro study
dc.subjectlymphocyte culture
dc.subjectmale
dc.subjectmutagenesis
dc.subjectnormal human
dc.subjectparacoccidioides brasiliensis
dc.subjectpriority journal
dc.subjectstructural chromosome aberration
dc.subjectAdult
dc.subjectAneuploidy
dc.subjectAntigens, Fungal
dc.subjectCells, Cultured
dc.subjectChromosome Aberrations
dc.subjectFungal Proteins
dc.subjectGlycoproteins
dc.subjectHumans
dc.subjectLymphocytes
dc.subjectMale
dc.subjectMetaphase
dc.subjectMitotic Index
dc.subjectMutagenicity Tests
dc.subjectOligosaccharides
dc.titleHuman chromosome aberrations induced in vitro by Paracoccidioides brasiliensis glycoproteic component (GP 43)
dc.typeArtigo


Este ítem pertenece a la siguiente institución