Effects of the application of α1- and α2-adrenoceptor agonists and antagonists into the ventromedial hypothalamus on the sodium and potassium renal excretion

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-26T21:57:47Z
dc.date.accessioned2022-10-05T17:22:47Z
dc.date.available2014-05-26T21:57:47Z
dc.date.available2022-10-05T17:22:47Z
dc.date.created2014-05-26T21:57:47Z
dc.date.issued1984-01-01
dc.identifierPharmacology, v. 28, n. 4, p. 228-234, 1984.
dc.identifier0031-7012
dc.identifierhttp://hdl.handle.net/11449/63648
dc.identifier10.1159/000137967
dc.identifier2-s2.0-0021362154
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3913843
dc.description.abstractThe effects of sodium and potassium excretion after intrahypothalamic administration of two α-adrenoceptor agonists and the effect of α-adrenoceptor antagonists were studied in groups of rats. Prazosin was equally effective at blocking the natriuretic and kaliuretic responses to the α1-adrenoceptor agonist phenylephrine and the mixed α1/α2-adrenoceptor agonist noradrenaline, while yohimbine which acts preferentially on α2-adrenoceptors was effective in potentiating these responses. These results suggest the presence of two types of α-adrenoceptors for the modulation of ventromedial hypothalamic pathways that interfere with the regulation of the two cations: stimulation of α1-adrenoceptors facilitates, while stimulation of α2-adrenoceptors inhibits the excretion of the ions.
dc.languageeng
dc.relationPharmacology
dc.relation1.538
dc.relation0,502
dc.rightsAcesso restrito
dc.sourceScopus
dc.subjectalpha 1 adrenergic receptor
dc.subjectalpha 2 adrenergic receptor
dc.subjectalpha adrenergic receptor stimulating agent
dc.subjectnoradrenalin
dc.subjectphenylephrine
dc.subjectprazosin
dc.subjectyohimbine
dc.subjectanimal experiment
dc.subjectcentral nervous system
dc.subjectkidney
dc.subjectnonhuman
dc.subjectpotassium urine level
dc.subjectrat
dc.subjectsodium urine level
dc.subjectzona incerta
dc.subjectAdrenergic alpha-Agonists
dc.subjectAdrenergic alpha-Antagonists
dc.subjectAnimal
dc.subjectDogs
dc.subjectDose-Response Relationship, Drug
dc.subjectHypothalamus, Middle
dc.subjectNorepinephrine
dc.subjectPhenylephrine
dc.subjectPotassium
dc.subjectPrazosin
dc.subjectRabbits
dc.subjectRats
dc.subjectSodium
dc.subjectSupport, Non-U.S. Gov't
dc.subjectYohimbine
dc.titleEffects of the application of α1- and α2-adrenoceptor agonists and antagonists into the ventromedial hypothalamus on the sodium and potassium renal excretion
dc.typeArtigo


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