Physicochemical properties of sildenafil citrate (Viagra) and sildenafil base

Artigo

Fecha

2003-10-01

Registro en:

Journal of Pharmaceutical Sciences. Hoboken: John Wiley & Sons Inc., v. 92, n. 10, p. 2140-2143, 2003.

0022-3549

http://hdl.handle.net/11449/33046

10.1002/jps.10469

WOS:000185692500021

http://repositorioslatinoamericanos.uchile.cl/handle/2250/3905467

Autor

Universidade Federal de Mato Grosso do Sul (UFMS)

Universidade Estadual Paulista (Unesp)

Institución

Universidade Paulista Júlio de Mesquita Filho (Brasil)

Resumen

Sildenafil citrate (Viagra) [I] and sildenafil base [II] are easily and unequivocally characterized by a set of physicochemical methods that include X-ray diffractometry, infrared spectroscopy, and thermal analysis. Monoclinic lattice constants: [I]: a = 26.98 Angstrom; b = 11.95 Angstrom; c = 16.68 Angstrom; beta = 106.97degrees. [II]: a = 8.66 Angstrom; b = 34.27 Angstrom; c = 8.93 Angstrom; beta = 96.63'. Both compounds decompose at 189.4degreesC [I] and 251.9degreesC [II]. Densities and refractive indices are given. (C) 2003 Wiley-Liss, Inc.

Materias

Viagra

sildenafil citrate

sildenafil base

bioinorganic chemistry

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