Artigo
A chromene and prenylated benzoic acid from Piper aduncum
Fecha
1999-08-01Registro en:
Phytochemistry. Oxford: Pergamon-Elsevier B.V., v. 51, n. 7, p. 899-902, 1999.
0031-9422
10.1016/S0031-9422(99)00132-6
WOS:000081437800009
2518006820764120
4484083685251673
1308042794786872
Autor
Universidade Estadual Paulista (Unesp)
Universidade de São Paulo (USP)
Inst Bot
Resumen
In addition to nerolidol, 2',6'-dihydroxy-4'-methoxydihydrochalcone, methyl 2,2-dimethyl-8-(3'-methyl-2'-butenyl)-2H-1-chromene-6-carboxylate, methyl 2,2-dimethyl-2H-1-chromene-6-carboxylate and methyl 8-hydroxy-2,2-dimethyl-2H-1-chromene-6-carboxylate, two new natural products were isolated from the leaves of Piper aduncum, 2,2-dimethyl-2H-1-chromene-6-carboxylic acid and 3-(3',7'-dimethyl-2',6 '-octadienyl)-4-methoxybenzoic acid. The structures of the isolates were established based on analysis of spectroscopic data, including ES-MS. The DNA-damaging activity of the isolated compounds was also investigated against mutant strains of Saccharomyces cerevisiae. (C) 1999 Elsevier B.V. Ltd. All rights reserved.