Artigo
Triterpenes and antitubercular activity of Byrsonima crassa
Fecha
2008-01-01Registro en:
Química Nova. Sociedade Brasileira de Química, v. 31, n. 7, p. 1719-1721, 2008.
0100-4042
10.1590/S0100-40422008000700023
S0100-40422008000700023
WOS:000262432800023
S0100-40422008000700023.pdf
0000-0003-3032-2556
Autor
Universidade Estadual Paulista (Unesp)
Instituto Adolfo Lutz (IAL)
Resumen
We evaluated the potential antitubercular activity of triterpenes obtained from leaves and bark of Byrsonima crassa. From chloroform extracts of the leaves, by bioassay-guided fractionation, we obtained mixtures of known triterpenes: α-amyrin, β-amyrin and their acetates, lupeol, oleanolic acid, ursolic acid and α-amyrinone. Tested against Mycobacterium tuberculosis, the triterpenes exhibited minimum inhibitory concentrations (MICs) of 31.25 - 312.25 µg/mL. β-amyrin and friedelin, isolated from the chloroform extract of bark, showed MICs of 312.25 and 125 µg/mL respectively. This is the first report of the identification and determination of the activity of B. crassa triterpenes against M. tuberculosis.