Artigo
4,5-Seco-Guaiane and a Nine-Membered Sesquiterpene Lactone from Holostylis reniformis
Fecha
2012-12-01Registro en:
Molecules. Basel: Mdpi Ag, v. 17, n. 12, p. 14046-14057, 2012.
1420-3049
10.3390/molecules171214046
WOS:000312608200028
WOS000312608200028.pdf
5981353442037051
Autor
Universidade Estadual Paulista (Unesp)
Inst Rene Rachou FIOCRUZ
Universidade Federal de São Carlos (UFSCar)
Resumen
Root extracts of Holostylis reniformis (Aristolochiaceae) yielded three new natural sesquiterpenes, a sesquiterpene with an unusual carbon skeleton, 4,5-seco-guaiane (7-epi-11-hydroxychabrolidione A, 1), a nine-membered lactone with new carbon skeleton (holostylactone, 2), and a new megastigmane [(6S,7E)-6,9-dihydroxy-10-(2'-hydroxyethoxy)-4,7-megastigmadien-3-one, 3], together with bulnesol and sitosterol-3-O-beta-D-glucopyranoside. The structures of these compounds were determined by spectroscopic analyses and B3LYP/STO-3G** theoretical studies.