Cytotoxic Guanidine Alkaloids from Pterogyne nitens

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributorUniversidade Federal do Ceará (UFC)
dc.contributorInst Bot
dc.date.accessioned2014-05-20T14:20:11Z
dc.date.accessioned2022-10-05T15:19:57Z
dc.date.available2014-05-20T14:20:11Z
dc.date.available2022-10-05T15:19:57Z
dc.date.created2014-05-20T14:20:11Z
dc.date.issued2009-03-01
dc.identifierJournal of Natural Products. Washington: Amer Chemical Soc, v. 72, n. 3, p. 473-476, 2009.
dc.identifier0163-3864
dc.identifierhttp://hdl.handle.net/11449/26062
dc.identifier10.1021/np800612x
dc.identifierWOS:000264627600025
dc.identifier4702004904231248
dc.identifier1308042794786872
dc.identifier4484083685251673
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3899097
dc.description.abstractAs part of a bioprospecting program aimed at the discovery of potential anticancer drugs, two new guanidine-type alkaloids, nitensidines D and E (1, 2), and the known pterogynine (3), pterogynidine (4), and galegine (5), were isolated from the leaves of Pterogyne nitens. The structures of I and 2 were established on the basis of spectroscopic data interpretation. These compounds were tested against a small panel of human cancer cell lines. Compound 2 exhibited cytotoxicity for HL-60 (human myeloblastic leukemia) and SF-245 (human glioblastoma) cells.
dc.languageeng
dc.publisherAmer Chemical Soc
dc.relationJournal of Natural Products
dc.relation3.885
dc.relation1,368
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.titleCytotoxic Guanidine Alkaloids from Pterogyne nitens
dc.typeArtigo


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