Cytotoxic Guanidine Alkaloids from Pterogyne nitens

Artigo

Fecha

2009-03-01

Registro en:

Journal of Natural Products. Washington: Amer Chemical Soc, v. 72, n. 3, p. 473-476, 2009.

0163-3864

http://hdl.handle.net/11449/26062

10.1021/np800612x

WOS:000264627600025

4702004904231248

1308042794786872

4484083685251673

http://repositorioslatinoamericanos.uchile.cl/handle/2250/3899097

Autor

Universidade Estadual Paulista (Unesp)

Universidade Federal do Rio de Janeiro (UFRJ)

Universidade Federal do Ceará (UFC)

Inst Bot

Institución

Universidade Paulista Júlio de Mesquita Filho (Brasil)

Resumen

As part of a bioprospecting program aimed at the discovery of potential anticancer drugs, two new guanidine-type alkaloids, nitensidines D and E (1, 2), and the known pterogynine (3), pterogynidine (4), and galegine (5), were isolated from the leaves of Pterogyne nitens. The structures of I and 2 were established on the basis of spectroscopic data interpretation. These compounds were tested against a small panel of human cancer cell lines. Compound 2 exhibited cytotoxicity for HL-60 (human myeloblastic leukemia) and SF-245 (human glioblastoma) cells.

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