Evaluation of different media for the production of cephalosporins by Streptomyces clavuligerus ATCC 27064

Artigo

Fecha

2012-12-01

Registro en:

Brazilian Archives of Biology and Technology. Brazilian Archives of Biology and Technology, v. 55, n. 6, p. 819-825, 2012.

1516-8913

http://hdl.handle.net/11449/25248

10.1590/S1516-89132012000600003

S1516-89132012000600003

WOS:000313343000003

S1516-89132012000600003.pdf

2478051365107560

http://repositorioslatinoamericanos.uchile.cl/handle/2250/3898368

Autor

Universidade Estadual Paulista (Unesp)

Universidade Federal de São Carlos (UFSCar)

Institución

Universidade Paulista Júlio de Mesquita Filho (Brasil)

Resumen

The aim of this work was to compare the composition of a complex and soluble culture medium to eight other media described in the literature through the batch cultivation in a conventional bench-scale bioreactor for the production of cephamycin C by a wild strain of Streptomyces clavuligerus. The proposed medium resulted in an antibiotic production 1.5 to 7.5 times higher than the other culture media.

Materias

β-lactam antibiotic

Streptomyces clavuligerus

lysine metabolism

complex medium

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