The role of chemokines and chemokine receptors in eosinophil activation during inflammatory allergic reactions

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversity of Michigan
dc.creatorOliveira, Sandra Helena Penha de [UNESP]
dc.creatorLukacs, N.W.
dc.date2013-09-30T18:29:18Z
dc.date2014-05-20T13:43:05Z
dc.date2013-09-30T18:29:18Z
dc.date2014-05-20T13:43:05Z
dc.date2003-11-01
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2003001100002
dc.identifierBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 36, n. 11, p. 1455-1463, 2003.
dc.identifier0100-879X
dc.identifierhttp://hdl.handle.net/11449/14996
dc.identifier10.1590/S0100-879X2003001100002
dc.identifierS0100-879X2003001100002
dc.identifierS0100-879X2003001100002.pdf
dc.identifier8905977598945667
dc.descriptionChemokines are important chemotactic cytokines that play a fundamental role in the trafficking of leukocytes to sites of inflammation. They are also potent cell-activating factors, inducing cytokine and histamine release and free radical production, a fact that makes them particularly important in the pathogenesis of allergic inflammation. The action of chemokines is regulated at the level of agonist production and processing as well as at the level of receptor expression and coupling. Therefore, an analysis of the ligands must necessarily consider receptors. Eosinophils are target cells involved in the allergic inflammatory response since they are able to release a wide variety of mediators including CC and CXC chemokines and express their receptors. These mediators could damage the airway epithelial cells and might be important to stimulate other cells inducing an amplification of the allergic response. This review focuses on recently emerging data pertaining to the importance of chemokines and chemokine receptors in promoting eosinophil activation and migration during the allergic inflammatory process. The analysis of the function of eosinophils and their chemokine receptors during allergic inflammation might be a good approach to understanding the determinants of asthma severity and to developing novel therapies.
dc.descriptionUniversidade Estadual Paulista Faculdade de Odontologia de Araçatuba Departamento de Ciências Básicas
dc.descriptionUniversity of Michigan Medical School Department of Pathology
dc.descriptionUniversidade Estadual Paulista Faculdade de Odontologia de Araçatuba Departamento de Ciências Básicas
dc.format1455-1463
dc.languageeng
dc.publisherAssociação Brasileira de Divulgação Científica (ABRADIC)
dc.relationBrazilian Journal of Medical and Biological Research
dc.relation1.492
dc.rightsAcesso aberto
dc.sourceSciELO
dc.subjectChemokines
dc.subjectChemokine receptors
dc.subjectAllergic inflammation
dc.titleThe role of chemokines and chemokine receptors in eosinophil activation during inflammatory allergic reactions
dc.typeArtigo


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