KSHV genotypes A and C are more frequent in Kaposi sarcoma lesions from Brazilian patients with and without HIV infection, respectively

Artigo

Fecha

2011-02-01

Registro en:

Cancer Letters. Clare: Elsevier B.V., v. 301, n. 1, p. 85-94, 2011.

0304-3835

http://hdl.handle.net/11449/13043

10.1016/j.canlet.2010.10.011

WOS:000287108900010

5240998569868081

http://repositorioslatinoamericanos.uchile.cl/handle/2250/3888729

Autor

Universidade de São Paulo (USP)

Universidade Estadual Paulista (Unesp)

Institución

Universidade Paulista Júlio de Mesquita Filho (Brasil)

Resumen

The present study aimed to evaluate the frequency of KSHV genotypes isolated from Kaposi sarcoma (KS) lesions in patients from Brazil. Fifty KS cases were evaluated. The most frequently detected viral genotypes were A (50.0%) and C (48.0%); the B genotype was isolated only in one case (2.0%). Noteworthy, there was a significant predominance of A genotypes in KS lesions from HIV-positive patients, whereas C genotypes were found mostly in the HIV-negative setting. This finding supports the hypothesis that distinct KSHV genotypes have a non-random distribution in KS, which might be attributable to unique biological properties. (C) 2010 Elsevier B.V. All rights reserved.

Materias

KSHV

HHV-8

Kaposi sarcoma

Viral genotyping

Mostrar el registro completo del ítem