dc.contributor | Universidade Estadual Paulista (Unesp) | |
dc.contributor | Universidade Federal da Bahia (UFBA) | |
dc.contributor | Univ Luterana Brasil | |
dc.date.accessioned | 2014-05-20T13:36:54Z | |
dc.date.accessioned | 2022-10-05T13:49:47Z | |
dc.date.available | 2014-05-20T13:36:54Z | |
dc.date.available | 2022-10-05T13:49:47Z | |
dc.date.created | 2014-05-20T13:36:54Z | |
dc.date.issued | 2003-02-01 | |
dc.identifier | Cancer Science. Tokyo: Japanese Cancer Assoc, v. 94, n. 2, p. 188-192, 2003. | |
dc.identifier | 1347-9032 | |
dc.identifier | http://hdl.handle.net/11449/12700 | |
dc.identifier | 10.1111/j.1349-7006.2003.tb01417.x | |
dc.identifier | WOS:000182370200009 | |
dc.identifier | WOS000182370200009.pdf | |
dc.identifier | 3278528112652257 | |
dc.identifier | 5051118752980903 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/3888489 | |
dc.description.abstract | The modifying potential of crude extracts of the mushroom Agaricus blazei Murrill (Himematsutake) on the development and growth of glutathione S-transferase placental form (GST-P)-positive liver foci (liver preneoplastic lesion) was investigated in adult male Wistar rats. Six groups of animals were used. Groups 2 to 5 were given a single i.p. injection of 200 mg/kg b.w. of diethylnitrosamine (DEN) and groups 1 and 6 were treated with saline at the beginning of the experiment. After 2 weeks, animals of groups 3 to 6 were orally treated with three dose levels of aqueous extracts of the mushroom A. blazei (1.2, 5.6, 11.5, and 11.5 mg/ml of dry weight of solids) for 6 weeks. All animals were subjected to two-thirds partial hepatectomy at week 3 and sacrificed at week 8. Two hours before sacrifice, ten animals of each group were administered a single i.p injection of 100 mg/kg of bromodeoxyuridine (BrdU). Apoptotic bodies and BrdU-positive hepatocyte nuclei were quantified in liver sections stained for hematoxylin and eosin (H&E) (eosinophilic foci) and simultaneously stained for GST-P expression (GST-P-positive foci), respectively. The 6-week treatment with A. blazei did not alter the development (number and size) of GST-P-positive foci and did not affect the growth kinetics of liver normal parenchyma or foci in DEN-initiated animals. Our results indicate that the treatment with aqueous extracts of the mushroom A. blazei during the post-initiation stage of rat liver carcinogenesis does not exert any protective effect against the development of GST-P-positive foci induced by DEN. (Cancer Sci 2003; 94: 188-192). | |
dc.language | eng | |
dc.publisher | Japanese Cancer Assoc | |
dc.relation | Cancer Science | |
dc.relation | 1,744 | |
dc.rights | Acesso aberto | |
dc.source | Web of Science | |
dc.title | Agaricus blazei (Himematsutake) does not alter the development of rat diethylnitrosamine-initiated hepatic preneoplastic foci | |
dc.type | Artigo | |