Artigo
Morphometric study of placental villi and vessels in women with mild hyperglycemia or gestational or overt diabetes
Fecha
2007-10-01Registro en:
Diabetes Research and Clinical Practice. Clare: Elsevier B.V., v. 78, n. 1, p. 65-71, 2007.
0168-8227
10.1016/j.diabres.2007.01.023
WOS:000250130500011
0679387622604743
6758680388835078
1884059321499759
0000-0002-9227-832X
0000-0003-4074-252X
Autor
Universidade Estadual Paulista (Unesp)
Resumen
In this study, morphometric measures of placental terminal villi and villous vessels were compared in overt, as well as gestational diabetes mellitus, and mild hyperglycemia diagnosed by oral 100 g glucose tolerance test (100 g-OGTT) and glucose profile (GP). At delivery (gestational age >= 34 weeks) a total of 207 placentas were assigned to a control group (n = 56) or to one of three groups complicated by mild hyperglycemia (n = 5 1), gestational diabetes (n = 59) and overt diabetes (n = 4 1). Placenta samples were randomly selected for blind morphometric assessment with an image analyser. Morphometric measures obtained included area and number of terminal villi and their respective villous vessels. Statistical analyses were performed using the chi-square test, ANOVA and stepwise regression (p <= 0.05). Glycemic means were 86.2 mg/dL in controls, 98.9 mg/dL in mild hyperglycemia, 114.1 mg/dL in gestational diabetes and 122.1 mg/dL in overt diabetes. Our results show that abnormal maternal glycemic levels may change the placental morphometric characteristics related to materno-fetal exchanges. (C) 2007 Elsevier B.V.. All rights reserved.