Performance characteristics of bioassay UV-spectrophotometry and high perfomance liquid chromatographic determination of gatifloxacin in tablets

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:25:08Z
dc.date.accessioned2022-10-05T13:15:56Z
dc.date.available2014-05-20T13:25:08Z
dc.date.available2022-10-05T13:15:56Z
dc.date.created2014-05-20T13:25:08Z
dc.date.issued2008-01-01
dc.identifierQuímica Nova. Sociedade Brasileira de Química, v. 31, n. 7, p. 1831-1835, 2008.
dc.identifier0100-4042
dc.identifierhttp://hdl.handle.net/11449/7954
dc.identifier10.1590/S0100-40422008000700039
dc.identifierS0100-40422008000700039
dc.identifierWOS:000262432800039
dc.identifierS0100-40422008000700039.pdf
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/3884700
dc.description.abstractThe microbiological bioassay, UV-spectrophotometry and HPLC methods for assaying gatifloxacin in tablets were compared. Validation parameters such as linearity, precision, accuracy, limit of detection and limit of quantitation were determined. Beer's law was obeyed in the ranges 4.0-14.0 μg/mL for HPLC and UV-spectrophotometric method, and 4.0-16.0 μg/mL for bioassay. All methods were reliable within acceptable limits for antibiotic pharmaceutical preparations being accurate, precise and reproducible. The bioassay and HPLC are more specific than UV-spectrophotometric analysis. The application of each method as a routine analysis should be investigated considering cost, simplicity, equipment, solvents, speed, and application to large or small workloads.
dc.languageeng
dc.publisherSociedade Brasileira de Química
dc.relationQuímica Nova
dc.relation0.646
dc.relation0,255
dc.rightsAcesso aberto
dc.sourceSciELO
dc.subjectfluoroquinolone
dc.subjectgatifloxacin
dc.subjectpharmaceutical analysis
dc.titlePerformance characteristics of bioassay UV-spectrophotometry and high perfomance liquid chromatographic determination of gatifloxacin in tablets
dc.typeArtigo


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