Artigo
Host-guest system of 4-nerolidylcatechol in 2-hydroxypropyl-beta-cyclodextrin: preparation, characterization and molecular modeling
Fecha
2009-06-01Registro en:
Journal of Inclusion Phenomena and Macrocyclic Chemistry. Dordrecht: Springer, v. 64, n. 1-2, p. 23-35, 2009.
0923-0750
10.1007/s10847-009-9532-y
WOS:000266009000003
Autor
Universidade Federal de Goiás (UFG)
Universidade Estadual Paulista (Unesp)
Universidade de Brasília (UnB)
Universidade de São Paulo (USP)
Resumen
The interaction of 4-nerolidylcatechol (4-NRC), a potent antioxidant agent, and 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) was investigated by the solubility method using Fourier transform infrared (FTIR) methods in addition to UV-Vis, (1)H-nuclear magnetic resonance (NMR) spectroscopy and molecular modeling. The inclusion complexes were prepared using grinding, kneading and freeze-drying methods. According to phase solubility studies in water a B(S)-type diagram was found, displaying a stoichiometry complexation of 2:1 (drug:host) and stability constant of 6494 +/- A 837 M(-1). Stoichiometry was established by the UV spectrophotometer using Job's plot method and, also confirmed by molecular modeling. Data from (1)H-NMR, and FTIR, experiments also provided formation evidence of an inclusion complex between 4-NRC and HP-beta-CD. 4-NRC complexation indeed led to higher drug solubility and stability which could probably be useful to improve its biological properties and make it available to oral administration and topical formulations.