| dc.creator | Palomo G,Iván | |
| dc.creator | Pereira G,Jaime | |
| dc.creator | Alarcón L,Marcelo | |
| dc.creator | Pinochet P,Carmen | |
| dc.creator | Vélez SM,María T | |
| dc.creator | Hidalgo P,Patricia | |
| dc.creator | Skagerberg,Karin | |
| dc.creator | Poblete C,Fernando | |
| dc.date | 2005-12-01 | |
| dc.date.accessioned | 2017-03-07T15:35:14Z | |
| dc.date.available | 2017-03-07T15:35:14Z | |
| dc.identifier | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005001200003 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/387651 | |
| dc.description | Background: Factor V Leiden and G20210A mutation of prothrombin gene are two important genetic polymorphisms associated with an increased risk for thrombosis. Aim: To establish the prevalence of factor V Leiden and prothrombin G20210A mutation in the Chilean population and their association to venous and arterial thromboembolism. Material and methods: A case-control study was conducted where 149 patients with thrombosis (87 with arterial and 62 with venous thrombosis) confirmed by CAT-scan, electrocardiogram and cardiac enzymes or Doppler depending on the case, and 160 healthy blood donors were genetically analyzed for the presence of both polymorphisms. Results: Factor V Leiden mutation was found in 5.4% of patients and in 1.3% of healthy controls (p=0.04). Heterozygosity for G20210A prothrombin mutation was found in 5.4% of patients and in 2.5% of the control group (p=NS). When arterial and venous thrombosis were considered as separate entities, 4.6% of patients with arterial thrombosis and 6.5% with venous thrombosis presented factor V Leiden (p=NS). Likewise, 8.1% of patients with venous thrombosis and 3.5% of patients with arterial thrombosis had G20210A prothrombin mutation (p=NS). Conclusions: In non selected consecutive Chilean patients with arterial and venous thrombosis the frequency of factor V Leiden and prothrombin G20210A is less than we could expect from their prevalence in the general population (Rev Méd Chile 2005; 133: 1425-33) | |
| dc.format | text/html | |
| dc.language | es | |
| dc.publisher | Sociedad Médica de Santiago | |
| dc.source | Revista médica de Chile v.133 n.12 2005 | |
| dc.subject | Factor V | |
| dc.subject | deficiency | |
| dc.subject | Prothrombin | |
| dc.subject | Thromboembolism | |
| dc.subject | Venous thrombosis | |
| dc.title | Factor V Leiden y mutación de la protrombina G20210A en pacientes con trombosis venosa y arterial | |
| dc.type | Artículos de revistas | |
