SUMMARY: This research was carried out to verify the comparative effects of aspirin and ranitidine in the gastric mucosal repair after surgical agression. Standardized surgical incision was performed in gastric mucosa of 12 rats, divided equitably into 3 groups: placebo group (PG), aspirin group (AG) and ranitidine group (RG). Either stomach wall or abdominal wall were sutured in 2 plans. The rats of PG, AG and RG received daily intragastric administration of 1ml of distilled water, 250mg/kg of aspirin and 25mg/kg of ranitidine respectively. The studies of light microscopy and scanning electron microscopy of repair of mucosal incision on 7th post operatory day displayed reepithelization of granulation tissue. The severity of alterations was observed, on gastric mucosa of AG, PG and RG in decreasing order.