Monografia (especialização)
Desenvolvimento de vacinas para o HIV: é possível uma vacina?
Fecha
2013-10-04Autor
Isabelle Figueiredo Marques
Institución
Resumen
The HIV infection represents a major challenge for the Worldwide Public Health.
WHO. Data reveals that in 2010, 1.8 million people died of AIDS. From the beginning
of the HIV epidemic to June of 2011, Brazil had 608,230 AIDS cases reported. The
use of antirretroviral drugs, in spite of having proven efficiency, has limitations arising
from cost, adherence to treatment by patients and undesirable adverse effects.
Considering the devastating disease situation around the world and especially in the
Sub-Saharan Africa region, It is vital the development of an effective protective
vaccine to contain the high rates of morbidity and mortality resulting from infection by
HIV. This work presents the disease’s history and the research related to the fight
against HIV, emphasizing information relating to advances in research of a safe and
effective vaccine. In addition, it assesses the limitations imposed to its development
stemming from the great genetic variability of the virus, lack of knowledge of the
cellular and humoral immune responses and the virus-host interaction processes, as
well as ethical implications.