Artículos de revistas
Comparative effect of Maitake Pro4x with chemotherapy breast cancer treatment
Fecha
2017Registro en:
0974-8369
10.4172/0974-8369.1000394
Autor
Aguilera Braico, Diego
Roldán Deamicis, Agustina
Brie, Belén
Balogh, Gabriela Andrea
Institución
Resumen
Abstract: Background: Conventional treatments for breast cancer involve surgery followed by radiation and hormonal
therapy and/or chemotherapy. Some of these treatments have toxic side effects. Because drugs used in
chemotherapy affect both cancer and normal cells to varying degrees, researchers are currently developing targeted
drugs that only attack cancer cells without affecting normal cells. One approach to this is to found compounds that
are more selective and specific, destroying only tumour cells and prevent metastases without harming normal cells.
For thousands of years, medicinal mushrooms have been used because of their healing properties. Maitake (Grifola
frondosa) is one of the most promising edible and medicinal mushroom, acting promoting the immune system
against the tumorigenesis process.
Methods: In the in vitro studies, we measured and compared the effect of Maitake Pro4X or Chemotherapy on
LM3 Breast Tumour Cells death. Increased concentrations and different time of treatments were employed. In the in
vivo studies, we employed breast tumour bearing female BALBc mice 6-8 weeks old, to assayed the effect of
Maitake Pro4X with or without chemotherapy measuring the tumour volume, mortality, relative survival and size of
tumour necrosis area after treatment.
Results: After 5 weeks of treatment in tumour-bearing BALBc mice, we observed that Maitake Pro4X significantly
increased the overall survival of animals and reduced the malignancy of breast tumours. We also found that Maitake
Pro4X, as chemotherapy, induce cell-death in a dose and time dependent form.
Conclusion: The beneficial effects of Maitake D-Fraction Pro4X, if supported by further evidence could be useful
for the treatment of cancer patients to reduce the adverse effects of the conventional chemotherapy treatment.