Artículos de revistas
Correlative structural, biochemical and behavioral study in neuroprotection with palmitoylehanolamide after perinatal asphyxia in the immature brain
Fecha
2019Registro en:
1431-9276 (impreso)
1435-8115 (on line)
10.1017/S1431927619006500
Autor
Herrera, María Inés
Kobiec, Tamara
Udovin, Lucas Daniel
Toro-Urrego, Nicolás
Kusnier, Carlos Federico
Luaces, Juan Pablo
Kölliker Frers, Rodolfo
Capani, Francisco
Institución
Resumen
Abstract: Perinatal asphyxia (PA) is an obstetric complication associated with an impaired gas exchange.
Diminish in the oxygen levels prompted short and long-term alterations in synapses and related
structures that are related to neuronal dysfunction and death. This serious health problem could lead to
neonatal mortality and continues to be a determinant of several neurodevelopmental disorders. The lack
of knowledge about the proper neuroprotective agents prompted us to investigate the role of
Palmitoylethanolamide (PEA) in the experimental treatment of PA. This natural occurring amide has
exerted protective effects in several models of brain injury and neurodegeneration.