Artículos de revistas
AZORELLANE DITERPENOIDS FROM LARETIA ACAULIS, AND ITS TOXOPLASMACIDAL ACTIVITY
Autor
LOYOLA,LUIS A.
BORQUEZ,JORGE
MORALES,GLAUCO
ARAYA,JORGE
GONZALEZ,JORGE
NEIRA,IVAN
SAGUA,HERNAN
SAN-MARTÍN,AURELIO
Institución
Resumen
In addition to azorellanol a new diterpenoid 7-deacetylazorellanol, has been isolated from the aerial parts of Laretia acaulis (Cav.) Gill et Hook (Umbelliferae). Its structure was based on spectroscopic comparison with azorellanol and chemical grounds. Azorellanol and 7-deacetylazorellanol showed marked inhibitor activity against trophozoites of protozoan parasite Toxoplasma gondii. The 50 % inhibitory dose for azorellanol was calculated in 54 muM and for 7-deacetylazorellanol was 42 mM.