Artículos de revistas
Regulatory mechanisms of cAMP levels as a multiple target for antiplatelet activity and less bleeding risk
Registro en:
THROMBOSIS RESEARCH 134 (2): 221-226
0049-3848
Autor
Fuentes, E.
Palomo, I.
Institución
Resumen
Univ Talca, Fac Hlth Sci, Dept Clin Biochem & Immunohaematol, Interdisciplinary Excellence Res Program Healthy, Talca, Chile. Fuentes, E (Fuentes, Eduardo); Palomo, I (Palomo, Ivan) Platelet activation is a critical component of atherothrombosis. The multiple pathways of platelet activation limit the effect of specific receptor/pathway inhibitors, resulting in limited clinical efficacy. Recent research has confirmed that combination therapy results in enhanced antithrombotic efficacy without increasing bleeding risk. In this way, the best-known inhibitor and turn off signaling in platelet activation is cAMP. In this article we discuss the mechanisms of regulation of intraplatelet cAMP levels, a) platelet-dependent pathway: Gi/Gs protein-coupled receptors, phosphodiesterase inhibition and activation of PPARs and b) platelet-independent pathway: inhibition of adenosine uptake by erythrocytes. With respect to the association between intraplatelet cAMP levels and bleeding risk it is possible to establish that compounds/drugswith pleitropic effect for increased intraplatelet cAMP level could have an antithrombotic activity with less risk of bleeding. (C) 2014 Elsevier Ltd. All rights reserved.