Artículos de revistas
Synthesis, antimycobacterial activities and cytotoxicity on V79 of 3-[4′-Y-(1,1′-biphenyl)-4-yl]-N,N-dimethyl-3-(4-X-phenyl)-2-propen-1-amine derivatives
Registro en:
European Journal of Medicinal Chemistry 36 (10): 843-850
0223-5234
Autor
de Souza, A.O.
Junior, R.R.S.
Ferreira-Julio, J.F.
Rodriguez, J.
Melo, P.S.
Haun, M.
Sato, D.N
Duran, N.
Institución
Resumen
Rodriguez, J. Departamento de Ciencias Biomedicas, Facultad de Ciencias de la Salud, Universidad de Talca, Casilla 747, Talca, Chile. The derivatives of 3-(4′-bromo-[1,1′-biphenyl]-4-yl)-3-(4-X-phenyl)-N,N-dimethyl-2-propen-1-amine (5a–m) were synthesised through a Friedel–Crafts acylation followed by Wittig reaction. The effects of the compounds on standard strains of Mycobacterium sp. (ATCC) and M. tuberculosis isolated from clinical specimens were evaluated. Also the toxicity was determined on V79 cells line using neutral red uptake (NRU), nucleic acid content (NAC) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction to measure the cellular viability.