Activity of solidagenone and their semisynthetic derivatives on the glucocorticoid-mediated signal transduction

dc.creator	Razmilic, I.
dc.creator	Schmeda-Hirschmann, G.
dc.date	2008-01-10T15:05:58Z
dc.date	2008-01-10T15:05:58Z
dc.date	2000
dc.date.accessioned	2017-03-07T14:44:36Z
dc.date.available	2017-03-07T14:44:36Z
dc.identifier	Planta Medica 66 (1):86-88
dc.identifier	0032-0943
dc.identifier	http://dspace.utalca.cl/handle/1950/4331
dc.identifier.uri	http://repositorioslatinoamericanos.uchile.cl/handle/2250/372101
dc.description	Razmilic, I.; Schmeda-Hirschmann, G. Instituto de Quimica de Recursos Naturales, Universidad de Talca, Talca, CHILI.
dc.description	The labdane diterpene solidagenone and four semisynthetic derivatives were assessed for effects on the glucocorticoid-mediated signal transduction. Solidagenone and the derivatives proved to be active with IC[50] values between 1 and 25 μg/mL. All compounds were cytotoxic towards L 1210, BHK and COS 7 cells with IC[50] from 10-100 μg/mL.
dc.format	2946 bytes
dc.format	text/html
dc.language	en
dc.publisher	George Thieme
dc.subject	Diterpene ; Rhizome ; Biological activity ; Signal transduction ; Glucocorticoid ; Antiinflammatory agent ; Plant origin ; Pharmacognosy ; Medicinal plant ; Chile ; Compositae ; Dicotyledones ; Angiospermae ; Spermatophyta ; South America ; America ;
dc.title	Activity of solidagenone and their semisynthetic derivatives on the glucocorticoid-mediated signal transduction
dc.type	Artículos de revistas