Biological activity and xanthine oxidase inhibitors from Scirpus californicus (C A Mey) Steud

dc.creator	Schmeda-Hirschmann, G.
dc.creator	Gutierrez, M.I.
dc.creator	Loyola, J.I.
dc.creator	Zuniga, J.
dc.date	2007-12-26T22:29:06Z
dc.date	2007-12-26T22:29:06Z
dc.date	1996
dc.date.accessioned	2017-03-07T14:44:07Z
dc.date.available	2017-03-07T14:44:07Z
dc.identifier	Phytotherapy Research 10 (8): 683-685
dc.identifier	0951-418X
dc.identifier	http://dspace.utalca.cl/handle/1950/4282
dc.identifier.uri	http://repositorioslatinoamericanos.uchile.cl/handle/2250/371973
dc.description	Schmeda-Hirschmann, G. Departamento de Ciencias Biologicas, Universidad de Talca, Casilla 747, Talca, Chile.
dc.description	The methanol extract of the rhizomes of Scirpus californicus (Cyperaceae) inhibited the enzyme xanthine oxidase (XO) in vitro. Bioassay-guided isolation led to piceatannol, scirpusin A and scirpusin B as the main XO inhibitors of S. californicus. Piceatannol, scirpusin A and B were mixed-type inhibitors of the XO with Ki values of 1.1×10-4, 6×10-4 and 5×10-5 M, respectively. The extract and above mentioned compounds were marginally active as hypotensors when tested in normotensive rats at 2.5 mg/kg and were inactive towards the DNA binding assay in vitro
dc.format	2942 bytes
dc.format	text/html
dc.language	en
dc.publisher	John Wiley & Sons Ltd.
dc.subject	Scirpus californicus; Cyperaceae; xanthine oxidase inhibition; piceatannol; scirpusin A and B
dc.title	Biological activity and xanthine oxidase inhibitors from Scirpus californicus (C A Mey) Steud
dc.type	Artículos de revistas