Artículos de revistas
Gastroprotective activity of the diterpene solidagenone and its derivatives on experimentally induced gastric lesions in mice
Registro en:
Journal of Ethnopharmacology 81(1): 111-115
0378-8741
Autor
Schmeda-Hirschmann, G.
Rodriguez, J.
Astudillo, L.
Institución
Resumen
Schmeda-Hirschmann, G.; Astudillo L. Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla Talca, 747, Chile.
Rodriguez, J. Instituto de Biología Vegetal y Biotecnología, Universidad de Talca, Casilla 747, Talca, Chile. The labdane diterpene solidagenone 1 and its semisynthetic and biotransformations products 2–7 were assessed for gastroprotective effect in the HCl·EtOH-induced lesions in mice. At 100 mg/kg, solidagenone presented a statistically significant gastroprotective effect (P<0.05) comparable to lansoprazole at 20 mg/kg. The presence of the furan ring was required for the activity of solidagenone while hydroxylation at C-3 or C-6 afforded products with different activity associated with the stereochemistry. Solidagen-6β-ol 7 and 3α-hydroxysolidagenone 2 presented higher activity than solidagenone itself, while its epimers were inactive