Evaluación de nanopartículas de sílice mesoporosa obtenida de la cascarilla de arroz como sistema de liberación controlada del letrozol

Abstract

The use of conventional medications has brought with it different side effects in the human body as a result of the immediate release of the active substance. In addition, rice husk is an agricultural waste generated in large quantities causing pollution problems. Therefore, this research proposal assessed the release kinetics of letrozole using as support material the mesoporous silica nanoparticles obtained from the rice husk. The synthesis of the nanoparticles was performed using the Sol-gel method and characterized by FTIR and TEM. The results obtained showed a controlled release with prolonged action, better adjusting to the first order kinetic model because letrozole is released proportionally to the concentration gradient.