Phytochemicals containing biologically active polyphenols as an effective agent against Covid-19-inducing coronavirus
Autor
Chojnacka, K.
Witek-Krowiak, A.
Skrzypczak, D.
Mikula, K.
Młynarz, P.
Institución
Resumen
The outbreak of Covid-19 disease caused by SARS-CoV-19, along with the lack of
targeted medicaments and vaccines, forced the scientific world to search for new antiviral
formulations. In this review, we describe the current knowledge about plant extracts
containing polyphenols that inhibit Covid-19. Many plant-derived natural compounds
(polyphenols) might provide a starting point for the research on the use of plant extracts in
coronavirus treatment and prevention. Antivirus polyphenolic drugs can inhibit coronavirus
enzymes, which are essential for virus replication and infection. This group of natural
substances (betulinic acid, indigo, aloeemodine, luteolin, and quinomethyl triterpenoids,
quercitin or gallates) is a potential key to designing antiviral therapies for inhibiting viral
proteases. The known pharmacophore structures of bioactive substances can be useful in the
elaboration of new anti-Covid-19 formulations. The benefit of using preparations containing
phytochemicals is their high safety for patients and no side effects.