Immune characteristics of severe and critical COVID-19 patients
Autor
Yang, Li
Gou, Jianjun
Gao, Jianbo
Huang, Lan
Zhu, Zhiqiang
Ji, Shaofei
Liu, Hongchun
Xing, Lihua
Yao, Mengying
Zhang, Yi
Institución
Resumen
Recently, the novel coronavirus disease (COVID-19) has broken out
worldwide,1 with rapid increase of infected patients. COVID-19
dominantly leads to pneumonia.2 Among these COVID-19 patients,
some appears to be severe symptoms with acute respiratory distress
syndrome, organ failure,2 and further present a poor outcome.
Previous studies have been reported that immune patterns are
closely associated with disease progression of patients infected with
other viruses.3 The correlation between immune signatures and
outcome of severe and critical COVID-19 cases was not well
illuminated. Therefore, we aimed to evaluate the correlation between
immune characteristics, especially levels of lymphocytes and
cytokines in peripheral blood, and clinical parameters in severe and
critical COVID-19 patients, in order to find critical indicators of disease
progression and to provide important guides for therapeutic strategy.
Thirty-six adult cases with severe and critical COVID-19 were
enrolled. The disease outcome, immune patterns, microbiota infection, coagulation profile, and organ dysfunction biomarkers were
analyzed and collected. This project was approved by the Ethics
Committee of our hospital (No. 2020-KY-060), and all patients signed
the informed consent