2020 update on human coronaviruses: one health, one world
Autor
Zhao, Xinbin
Ding, Yuecheng
Du, Jing
Fan, Yubo
Institución
Resumen
Since human coronavirus (HCoVs) was first described in the 1960s, seven strains
of respiratory human coronaviruses have emerged and caused human infections. After
the emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) and
Middle East respiratory syndrome coronavirus (MERS-CoV), a pneumonia outbreak
of coronavirus disease 2019 (COVID-19) caused by a novel coronavirus
(SARS-CoV-2) has represented a pandemic threat to global public health in the 21st
century. Without effectively prophylactic and therapeutic strategies including vaccines
and antiviral drugs, these three coronaviruses have caused severe respiratory
syndrome and high case-fatality rates around the world. In this review, we detail the
emergence event, origin and reservoirs of all HCoVs, compare the differences with
regard to structure and receptor usage, and summarize therapeutic strategies for
COVID-19 that cause severe pneumonia and global pandemic